Calibration bracketing is a method that takes care of the changing conditions for the analysis during the measurement of larger volumes of samples.
Under normal conditions, there is a calibration standard (or standards) measured at the beginning of the sequence, followed by a number of samples. The analyte concentrations are calculated from the standard measured at the beginning of the sequence. Then, the recalibration is performed, and a new set of samples is measured based on the recalibrated results, and so on.
As it may be clearly seen, the concentrations in particular samples are calculated from the calibration that was measured in a different time of the sequence, possibly under slightly different conditions.
When the calibration bracketing is used, the concentrations of analytes in a sample are not calculated from the single set of calibration standards measured prior the analysis of the sample, but from the average of responses for the standard measured prior to the analysis of the sample and the standard measured after the analysis of the sample. This approach creates lesser error in the measured concentrations when the response shifts because of the changing analysis conditions.
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Internal issue tracking ID: 30180
IMPLEMENTED - Calibration bracketing
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- Daniel Mentlik
- DataApex Support
- Posts: 354
- Joined: Fri Mar 27, 2009 3:15 pm
IMPLEMENTED - Calibration bracketing
Last edited by Daniel Mentlik on Fri Jan 21, 2011 5:44 pm, edited 2 times in total.
Reason: issue tracking ID
Reason: issue tracking ID
Daniel Mentlík
DataApex
DataApex
Re: Calibration bracketing
Bracketed calibration is so important for long runs. I thought there would be hundred names on the list voting for this by now!
Dr Stuart Jones
Re: Calibration bracketing
Calibration bracketing is implemented since Clarity version 3.0.2.244
Ivan Vinš